Apr
01
2014

Welcome to the SRI Forum

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As mentioned in the tagline of this forum, the purpose is to facilitate a dialog around the Strategic Resource Investment initiative (SRI).  This forum is a place members of the University of Memphis community can ask questions and express concerns or comments as we go through the development of our model for SRI.  The webpages for the initiative (www.memphis.edu/sri) will continue to be updated with more detailed information and the current status of the initiative.  Any suggestions for improvements, corrections, or clarifications to this website are also greatly appreciated.

There have been several questions that have come from discussions with Deans and Department Chairs and we will start the dialog by addressing several of those over the next few posts.  In this post, I want to focus on a few common points about the philosophy of our SRI initiative.   The underlying goal is to develop a more transparent procedure for the allocations of the resources of the University – the people, facilities, and finances.  It is much more than a simple budget allocation process.  Much of the detail that will be discussed is on the allocation of revenues and costs but the true goal is to setup the conversations on the priorities and the allocation of resources to follow those priorities.

Within an SRI model, the financial responsibility and accountability, as well as resulting resources, are managed at the college level.  This is aligning the responsibility at the level of the people who have the best knowledge about our programs.  The recent plan eliminating the “central pool” for graduate student tuition is one example.  Going forward there will no longer be a central administration controlled pool of funds that are drawn from each year as those funds are now budgeted as part of the college budgets under their control.  There is no longer a blank check provided to departments for tuition as they award stipends to individual students.   This does mean colleges will have to be responsible for knowing and planning the complete cost of each student.  On the flip side, colleges will also have the ability to tailor the use of these funds in ways best suited for the graduate program within that college.

The above is just one example of how responsibilities are shifted out of the central administration to the college level along with direct benefits leading to revenue increases.    I hope you will all read the “Guiding Principles” and “What the Model Will/Will Not Do” sections of the SRI webpage.  We look forward to your feedback and further discussions as this new model is developed.

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    They share a common goal—to stimulate the pituitary gland to release more endogenous growth hormone—but they differ markedly in their structure, duration of action, safety
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    Below is an in-depth comparison that covers everything from basic
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    —

    What Peptides Are and How They Work in the Body

    Peptides are short chains of amino acids, typically ranging
    from three to fifty residues. Unlike small-molecule drugs, peptides
    often mimic naturally occurring signaling molecules in the
    body. When administered, they bind to specific receptors on target cells, initiating a cascade
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    Growth hormone releasing hormones (GHRHs) and growth
    hormone releasing peptides (GHRPs) are subclasses that act on the pituitary gland.
    They stimulate the secretion of growth hormone (GH), which in turn promotes
    the release of insulin-like growth factor 1 (IGF-1) from the liver and other tissues.
    IGF-1 drives anabolic processes such as protein synthesis,
    cell proliferation, and tissue repair while also influencing metabolism.

    The key steps are:

    Administration – Peptides are usually injected subcutaneously or intramuscularly because they are broken down in the digestive tract.

    Receptor Binding – The peptide reaches the pituitary and binds to its specific receptor (e.g., GHRH receptor for sermorelin, ghrelin receptor for CJC-1295 IPAMORELIN).

    Signal Transduction – Binding triggers intracellular signaling
    pathways that increase GH synthesis and release.

    Systemic Effects – Released GH circulates, binds to GH receptors on various tissues, stimulates IGF-1 production,
    and elicits downstream effects such as muscle growth, fat metabolism, immune modulation, and tissue repair.

    Because peptides are designed to work with the body’s
    own regulatory systems, they generally have a
    more natural feedback loop. When GH levels rise, negative feedback
    reduces further release, which helps prevent extreme hormonal imbalance.

    Sermorelin vs. CJC-1295 IPAMORELIN: Structural and Pharmacological Differences

    Feature Sermorelin CJC-1295 IPAMORELIN

    Origin Synthetic analog of the naturally occurring 44-amino-acid peptide GHRH (somatotropin releasing
    hormone). Combination of two peptides: a modified GHRH analogue (CJC-1295) and
    a selective ghrelin mimetic (IPAMORELIN).

    Half-life ~30 minutes to 1 hour. Requires multiple daily
    injections for steady GH stimulation. 36–48 hours due
    to attachment of a PEG moiety (PEGylation), allowing once-weekly dosing.

    Mechanism Binds GHRH receptor → stimulates GH release.

    Dual action: CJC-1295 binds GHRH receptor; IPAMORELIN binds ghrelin receptor, synergistically boosting GH
    secretion and prolonging the effect.

    Peak GH Levels Moderate peaks, closely mimic natural circadian rhythm.
    Higher peak GH and sustained elevation due to longer half-life.

    Side-Effects Profile Mild, often transient; may include injection site irritation,
    headache, or mild flushing. Similar to sermorelin but prolonged exposure can increase
    risk of edema or joint pain in susceptible individuals.

    Clinical Uses Growth hormone deficiency (GHD), pediatric growth disorders,
    and as a diagnostic tool for GH secretion testing. GHD, anti-aging protocols, athletic performance enhancement, and
    research into metabolic diseases.

    —

    CJC-1295 and IPAMORELIN for Lyme Disease: How Growth Hormone Peptides Support Healing

    Lyme disease is an infectious illness caused by Borrelia burgdorferi transmitted through tick bites.
    Chronic or post-treatment Lyme disease syndrome (PTLDS) can manifest
    as fatigue, joint pain, cognitive difficulties, and immune dysfunction. While antibiotics are the primary
    treatment for active infection, many patients experience
    lingering symptoms that may benefit from adjunctive therapies.

    3.1 Immune Modulation

    GH/IGF-1 Axis: Growth hormone has immunomodulatory
    properties. It enhances natural killer cell activity, promotes cytokine
    production (e.g., IL-2), and supports macrophage function.

    Antimicrobial Peptide Induction: IGF-1 can stimulate the expression of antimicrobial
    peptides such as cathelicidins, which may help control
    residual bacterial load.

    3.2 Anti-Inflammatory Effects

    Chronic Lyme disease is associated with persistent low-grade inflammation. GH and IGF-1 downregulate pro-inflammatory cytokines (TNF-α,
    IL-6) while upregulating anti-inflammatory mediators (IL-10).

    This shift can reduce joint pain and systemic fatigue.

    3.3 Tissue Repair and Regeneration

    Musculoskeletal Recovery: GH promotes collagen synthesis and fibroblast proliferation, aiding in the repair of damaged cartilage or ligaments that may be affected by
    Lyme-related inflammation.

    Neural Protection: IGF-1 supports neuronal survival and
    remyelination, potentially improving neuropathic pain dianabol pictures before and after cognitive symptoms.

    3.4 Metabolic Support

    Many patients with PTLDS report low energy levels.

    GH improves lipid metabolism (increasing lipolysis) and enhances glucose uptake in muscle tissues,
    thereby supporting overall vitality.

    3.5 Practical Considerations for Lyme Patients

    Start Low – Begin with a lower dose of CJC-1295 IPAMORELIN to gauge tolerance;
    many protocols recommend 2–4 µg per injection.

    Monitor IGF-1 – Periodic blood tests help ensure that IGF-1 stays within therapeutic
    ranges and avoids excessive levels that could lead to side effects such
    as edema or joint pain.

    Combine with Lifestyle Measures – Adequate sleep, balanced nutrition, and
    gentle exercise amplify the benefits of GH peptides.

    Adjunct Therapy – Antioxidants (vitamin C, selenium) may synergize with GH’s anti-oxidative properties to reduce oxidative stress common in chronic Lyme disease.

    Key Takeaways

    Different Potency and Duration: Sermorelin is a shorter-acting GHRH analogue suitable for daily dosing;
    CJC-1295 IPAMORELIN offers a longer half-life that allows
    weekly injections but delivers higher peak GH levels.

    Safety Profile: Both peptides are generally well tolerated, yet prolonged exposure to high GH can cause
    edema, joint discomfort, or mild insulin resistance.
    Monitoring is essential.

    Clinical Versatility: While sermorelin is primarily used for diagnosing and treating growth hormone deficiency, CJC-1295 IPAMORELIN finds broader application in anti-aging, athletic performance,
    and adjunctive conditions such as Lyme disease.

    Mechanistic Synergy: The dual action of CJC-1295 (GHRH receptor) and IPAMORELIN (ghrelin receptor) amplifies GH release, which may accelerate tissue repair, reduce
    inflammation, and improve energy metabolism—key
    aspects in chronic illnesses like Lyme disease.

    Personalization is Key: Effective use depends on individualized dosing schedules, regular monitoring of hormonal levels, and integration with overall health strategies.

    Final Thoughts

    Choosing between sermorelin and CJC-1295 IPAMORELIN hinges on the desired balance between convenience, potency,
    and safety. For patients seeking a more natural, physiologic GH pulse that mimics circadian rhythms, sermorelin may be preferable.
    Those who require sustained GH stimulation with fewer daily injections might lean toward CJC-1295 IPAMORELIN, especially when addressing complex conditions such as chronic Lyme disease where immune support, anti-inflammatory action, and tissue repair are critical.

    In all cases, a qualified medical professional should oversee therapy
    to tailor dosing, monitor side effects, and ensure that the benefits outweigh potential risks.

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  111. Elite feminine bodybuilders can take excessive doses of 10–20
    mg; nevertheless, such users can count on to experience masculinization results.
    Today, a dose of 15–30 mg per day is standard for bodybuilders desirous
    to experience important changes in muscular energy
    and measurement. Upon its launch in 1958, Dr.
    Ziegler really helpful an authentic dosage of 5–15 mg per day.

    This was sufficient to see significant enhancements
    in athletic efficiency.
    In order to supply perception into either side of the argument
    concerning the effects of steroids, it is just applicable that we focus on the
    benefits and the reason why a number of people use steroids.
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    serum cystatin C concentrations are much less affected by age,
    intercourse, race, and, most significantly, muscle mass (167).

    An open and sincere dialogue with healthcare professionals is
    essential for individuals considering or using steroids.
    It permits for the identification and monitoring of potential psychological results and may help individuals make informed choices
    about their overall well being and well-being. The use of
    steroids can have a major impression on an individual’s temper,
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    Steroids work by performing on androgen receptors which
    boosts muscle development. They can hurt the
    guts and trigger hormonal issues, which lowers intercourse drive.
    Utilizing them an excessive quantity of can lead to blood issues,
    prostate most cancers, and mental well being issues
    like mood swings and despair. Although currently a controlled substance within the US and
    the UK, it however stays well-liked among bodybuilders.

    Anadrol has also been used medically for osteoporosis and muscle wasting due to its glorious muscle progress effects, even in those people who don’t
    participate in common resistance training8.
    HGH is legally utilized in medicine to deal with some situations regarding development.
    Nonetheless, when it comes to efficiency enhancement or
    bodybuilding, it’s not authorized to obtain or use and
    not using a prescription.
    This can put them underneath elevated pressure, resulting in acute renal injury in analysis (18).
    Additional research exhibits that even tiny doses of oxandrolone (2.5 mg), when taken by boys affected by delayed puberty,
    can notably decrease endogenous testosterone production (17).
    However, it’s not merely strength and endurance athletes that may profit from Anavar, with some
    sprinters, swimmers, and boxers additionally utilizing Anavar to realize a aggressive edge.

    In our expertise, this effect can turn into everlasting, stopping men from having
    youngsters (15). We have had instances of Anadrol inflicting gynecomastia through the direct stimulation of estrogen receptors in the mammary gland.
    Gynecomastia (gyno) is when further breast tissue begins to form in a male.
    Our sufferers don’t expertise noticeable bloating or fluid retention on Anadrol if their
    food plan is clean and they’re already lean. Due to Anadrol causing noticeable quantities
    of extracellular fluid retention, it’s not the most optimum steroid for vascularity.

    References:

    Post Cycle Recovery Best Practices

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  112. Beginner cycles typically start with lower doses and shorter
    durations to gauge the body’s reaction. For example, a first-time user
    might eat Anavar at 60 mg per day for a interval
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    the place they can be bought over-the-counter at a nearby Walmart store or local pharmacy.

    It increases aggression and strength with out different
    hormones’ bulk and water retention. One of its original medical uses was to increase muscle energy in patients with muscular wasting circumstances, so greater bodybuilding doses will doubtless give
    you a fairly vital power improvement. Even although Anavar is
    what we think about to be a milder steroid in comparability with most others, it’s nonetheless an anabolic steroid.

    In some instances, corticosteroids may very well cause muscle loss when used long-term.
    Anabolic steroids contain synthetic types of testosterone, with androgen lessons used to
    assist deal with delayed puberty in males.
    Long-term use of steroids also can enhance the danger
    of delayed progress in children, thinning bones in older adults, and a worsening of underlying health circumstances, corresponding
    to hypertension and diabetes.
    Whether Or Not operating orals, injectables, or both, it’s essential to
    implement a well-structured Submit Cycle Therapy (PCT) and ongoing well being monitoring — together with common bloodwork — to mitigate risks and support restoration. Nevertheless, with more superior detection methods, any steroid testing is undertaken by competitions and authorities with the budget
    to make sure in-depth exams will pick up metabolites. You should not be stunned when these metabolites are still present weeks, months, and generally well
    over a 12 months after you’ve taken your final anabolic steroid dosage – no matter what that steroid’s half-life
    is. In many instances, using the substance can still be detected in trace quantities of the remaining
    metabolites lengthy after the compound has exceeded its energetic life within the physique.
    So, while a steroid will now not be offering you with
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    drug take a look at many weeks or even months later.
    There’s an enormous distinction between oral and injectable steroids so far as their affect on detection instances goes.
    Oral steroids are energetic nearly instantly and depart the body rapidly as
    they cross through the liver and are uncovered to metabolic processes.

    Different benefits of Anavar embrace enhancing stamina and
    vitality as a end result of it boosts red blood cells.

    The joint advantages of Anavar make it stand out above other chopping
    steroids and is considered one of my favourite issues about Anavar.
    Despite its popularity as a extremely effective steroid, it’s still a
    comparatively gentle oral compared with different compounds.

    Failure to leave gaps like this in-between cycles, in our experience, can result in permanent
    damage to the HPT (hypothalamic-pituitary-testicular) axis.
    Bodybuilders also stack trenbolone with Anadrol; however,
    this should be seen as highly toxic and an pointless stack for many customers.
    We have found that SERMs, corresponding to Nolvadex, effectively inhibit
    estrogenic exercise within the mammary glands with out affecting estrogen ranges.
    For me, having an choice where I don’t have to stab myself with stuff is a big plus.
    Moreover, other steroids can immediately stimulate estrogen receptors at a cellular level, corresponding to Anadrol, which doesn’t have
    the aromatase enzyme current. More potent SARMs
    might exacerbate natural testosterone to a bigger diploma, such as LGD-4033 and
    RAD a hundred and forty.
    But should you nonetheless intend to make use of it alone
    and don’t thoughts a bit of muscle loss and fat, beginning on the
    lowest tablet dose of 25mcg daily is the means in which to go.
    If you respond nicely, the option to extend to 50mcg may be considered, and benefits will undoubtedly enhance
    – as will attainable side effects. Relying on how the steroids are
    used, this will range from relatively small changes to the development of maximum masculine traits.
    So, though it’s not common, some feminine athletes
    and bodybuilders do select to make use of steroids for performance-enhancing benefits.
    When undertaken rigorously, these girls can achieve significant benefits while carefully
    controlling the unwanted effects. When you’re utilizing HCG during
    a cycle, you should cease it two weeks earlier
    than your identified anabolic steroid clearance time.

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