Human Epidermal Cell Growth In Lab Proves to be Answer to Diabetic Integumentary Ulcers

Diabetes is a growing epidemic in the United States.  The complications from this chronic illness include a decrease in peripheral circulation and healing is slow, therefore there is increased risk for infection.  The legs and feet are usually areas diabetic ulcers can occur.  In many cases amputation results because of non-healing, infected wounds.

Apligraf, a product made by Organogenesis, is a bi-layered, living cell based product and the only FDA approved product to heal leg and foot ulcers suffered by diabetics.  It contains living cells and structural proteins that mimic the epidermis and dermis.  This small, pink specimen is applied directly to a freshly debrided, medication free, cleaned wound.  It does not overlap the healed skin of the patient and if large enough wound, may need more than one application.  Once applied the first wound dressing remains on for 5-7 days.  As the application takes hold and starts a healthy healing process, it will change in color too.

Today’s scientific technology of cell reproduction in the lab has evolved the combination of bovine fibroblasts, and infant foreskins to produce a solution to limb loss because of infection and chronic illness.  Although this product doesn’t completely replicate the true human skin because it doesn’t contain sweat glands, blood vessels, hair follicles, melanocytes, macrophages, or lymphocytes,  it does help people speed up recovery from diabetic ulcers.  Ultimately this is a “fix” and not a desireable predicament to have to incur.  Many preventative measures can be taken by the aging diabetic to care for blood sugar levels, proper foot and skin care, and regular consultation with a health care team.  Apligraf was an amazing and exciting treatment I have personally witnessed in a clinical setting with wound care professionals at a local public hospital.  I was amazed at the technology we have used resourcefully to produce.  It makes you wonder how close we are to making this a new part of bionics.

www. organogenesis.com

“Wound Facts & Prevention”Apligraf: add life to healing.  26 Jun 2013 1:00pm. www. apligraf.com/professional/wound_facts_and_prevention/index.html

 

Stem Cell Research finds ways to improve Type 1 Diabetes cures.

Type 1 Diabetes (T1D) is a disorder involving insulin need because the beta cells of the pancreas have been destoyed by the immune system.  The pancreatic beta cells are needed for production of insulin.  The insulin in turn reduces the blood glucose level, keping the body in homeostasis.  Currently the treatment of most T1D is with periodic insulin injections.

Research has been on-going with possible stem cell treatment of the pancreas, renewing beta cell production for insulin.  New studies have found treatment with a new drug called Ig-GAD2 and stem cells can not only lead to  production of new beta cells, it repairs the blood vessels that support beta cell growth and insulin distribution.  Thus beta cell survival is greater and insulin production is renewed.  Research of cures for other autoimmune disorders may apply these findings as well.

As many people are affected by T1D and the need for insulin is a demand, new hope arises for a cure to such a chronic illness.  The possibilities of reversing a genetic illness is a glimmer of psychological and financial hope.  To find a way to reverse this illness is a way to give so many people a new way of life.  No more shots, daily finger-sticks, and timely planning of meals and snacks around the demand of glucose need.

1.)  Tortora, Derrickson.  Principles of Anatomy & Physiology, 13th ed.  New Jersey,     2012.

2.)  University of Missouri School of Medicine (2013, May 29).  Adult stem cells could hold key to cure type 1 diabetes. ScienceDaily.  Retrieved June 16, 2013, from http://www.sciencedaily.com/releases

The Bioengineered Kidney

The Bioengineered Kidney

The kidneys have many functions that enable us to continue living.  One function involves the filtering of the blood to remove all the waste products (1). The waste products are removed in the urine, which is released by the urethra (1). The kidneys also are involved in keeping our electrolyte balance, controlling our blood pressure, and they promote the production of red blood cells (1). Once the kidneys start to malfunction and or fail completely, the patient might have to get a kidney transplant (1).

Like all other organ transplants, the kidney transplant might not be compatible with the new body. However, there has been a recent breakthrough in the development on a new kidney using one’s own cells to bioengineer a new kidney (2). The discovery was made by Dr. Ott, an MD at the MGH Center for Regenerative Medicine whom has also created bioartificial hearts, lungs, and livers (2). The bioengineered kidney was transplanted into a rat and immediately started functioning by producing urine (2). Although at the moment this bioengineered kidney is functioning, it still does not work as good as a regular kidney (2). However, Dr. Ott and his team are just beginning and they have plans to continue their project; next time using a pig’s kidney, which is more like that of a human (2).

I believe this new bioengineered kidney is only the beginning of a new era and will impact society in a positive way. If Dr. Ott and his team are able to successfully bioengineer a human kidney, many lives will be changed. People will no longer have to wait forever for a kidney transplant. Also, the probability that the kidney will be rejected by the patient will decrease dramatically since the kidney will be specifically bioengineered from his or her own cells.

1). Wedro, Benjamin. “Kidney Failure.” MedicineNet.com. (2013): n. page. Web. 17 Apr. 2013.

2.) Massachusetts General Hospital. “Implantable, bioengineered rat kidney: Transplanted organ produces urine, but further refinement is needed.” ScienceDaily, 14 Apr. 2013. Web. 17 Apr. 2013.

 

Amenorrhea in female athletes

Hannah Livingston

Amenorrhea is the absence of menstruation. The most common causes of amenorrhea are pregnancy and menopause. However, it can be common for  female athletes, which results from reduced secretion of gonadotropin-releasing hormone, which decreases the release of LH and FSH (Tortura & Derrickson). One research study in particular looks at how exercise during puberty may be associated with primary amenorrhea and low mineral density, while exercise after puberty associates with secondary amenorrhea and bone loss. The case study compared 45 prepubertal female gymnasts, 36 retired female gymnasts and 50 controls.

Gymnasts and controls could not participate in the study if they were peri- or postpubertal, if they had anorexia nervosa, or exposure to oral contraceptives, anticonvulsants, or corticosteroids. Controls were excluded if they engaged in more than 6 h of weight-bearing exercise per week. The prepubertal gymnasts were training at an Olympic standard. They trained under supervision for 15-36 hours per week. Most of their training sessions lasted four hours and consisted of a warm up, routine training, and strength and stretching exercises (Journal of Bone and Mineral Research).

In the cross-sectional analyses, areal bone mineral density and primary amenorrhea in active prepubertal gymnasts was higher at the weight-bearing sites than the predicted average in the control group. The Z scores increased as the duration of training increased. During 12 months, the increase in areal bone mineral density and amenorrhea in the active prepubertal gymnasts was 30-85% greater than in controls. In retired gymnasts, areal bone mineral density and amenorrhea was higher as well, resulting in a correlation between intense athletic training and higher bone mineral density as well as amenorrhea (Journal of Bone and Mineral Research).

 

Gerard J. Tortora and Bryan Derrickson. Principles of Anatomy and Physiology. 13th ed., John Wiley and Sons, 2012.

Journal of Bone and Mineral Research. Exercise Before Puberty May Confer Residual Benefits in Bone Density in Adulthood. S. Bass G. Pearce. 2013.

Adult Brain development

The brain can still develop even after adolescense. Adults need to enhance thier plasticity. Plasicity is when you are able to adapt to new experiences. Being able to adapt to a new and different environment is a social and survival skills that everyone has to have. Being a adult means that life is constantly changing, you have to adapt to having children being married and new jobs. New findings on the adult brain establish two principles. First, the adult brain continues to grow and develop throughout our entire life. Second, brain development in adulthood is shaped mostly by outside stimuli. This new thinking means that we can do healthy “workouts” for our brains, as well as our bodies!

There are games like soduko and lumosity for example. Having new expereincese is the best thing you can do for your brain. Everytime you learn something new your brain creates new pathways. The brain and body are connected and exercise is good for the both of them. The brain increases new cell growth and mental abilities  20-30% from the stimulation of exercise. Our brains can not function properly without sleep. We all need 8 hours of sleep a night so that our brains will function properly. A diet of fruits and vegetable along with plent of water will benefit the brain and body and help everyone function better.

 

Sources: J. Tortora, Gerald, and Bryan Derrickson. Principles of Anatomy and Physiology. 13th ed. John Wiley & Sons, Inc. Hoboken NJ, USA  2012.

“The Adult Brain.” Brain Institute Oregan Health and Science University OHSU is an equal opportunity affirmative action institution 2001-2013.

Nonsurgical Treatment Turns Back the Clock, Shrinks Enlarged Prostate

The prostate plays an important role as it makes up 25% of the volume of semen that helps sperm in both mobility and survival (Tortora and Derrickson 2012). It continually grows to expand until about age 30 when expansion stops, but then at age 45 it continues to grow once again (Tortora and Derrickson 2012). However, a current U.S. trial of a new nonsurgical procedure called prostatic artery embolization is helping in reducing the prostate enlargement (ScienceDaily). Shrinking of the prostate will counteract many of the symptoms of enlarged prostates without the potential risks that surgery can have (ScienceDaily).

Prostatic artery embolization was performed in Europe and South America with a correlation between the treatment and prostate size (ScienceDaily). This treatment is being carried out in Inova Alexandria Hospital in Alexandria, Virginia headed by Sandeep Bagla, M.D. (ScienceDaily). Prostatic artery embolization works by blocking the flow of blood to the prostate artery and therefore causing a decrease in the size of the prostate (ScienceDaily). Prostate enlargement occurs more frequently in older men and prostate size increases with older age, and because most men don’t choose surgical procedures many of them are prone to bladder stones, poor kidney functions, and infections (ScienceDaily).

As modern medicine continues to allow for humans to live a longer period of time higher incidents of prostate enlargement increases therefore diminishing the lifestyle of many elderly men. This treatment is a great option for those that don’t want to risk impotence, leaking urine, or infection that can come from surgery (ScienceDaily). Patients treated with PAE have had great results with 92% seeing an improvement of their symptoms (ScienceDaily). This is a treatment with the potential to alleviate or rid of the symptoms of enlarged prostates with a quick and easy treatment that has had great success in the clinical studies.

Tortora G.J. and B. Derrickson. 2012. Principles of Anatomy and Physiology. 13th ed., John Wiley and Sons

Society of Interventional Radiology. “Nonsurgical treatment turns back the clock, shrinks enlarged prostate.”ScienceDaily, 15. Apr. 2013. Web. 17 Apr. 2013.

Twith or Tic???

Twitch or Tic???

Have you ever been sitting in class and all of a sudden your eye lid starts twitching? Well guess what? You could have a tic! Our book gives the example of our eyelids twitching as a tic! The definition is “a spasmodic twitching made involuntarily by muscles that are ordinarily under voluntary control”. So really, every time your eyelid twitches, it’s a tic. Don’t worry though, this does not mean you actually have tics. Tics are just a form of twitches.

WebMD.com tells us that most of the time twitches and tics are harmless, but on some occasions it may be a disorder. Tic disorders have repetitive and numerous twitches. They can actually be suppressed, but it can cause major discomfort to the person. It is not really known as to what causes tics, but lack of sleep and stress seem to play a role. Twitches, on the other hand, are what most people experience. These only happen on occasions and are completely involuntary. Extreme cases of eye twitches are called Blepharospasms, which can resemble an eye blinking tic. However, as stated earlier, the tic is controllable while the twitch is not. A twitch or a tic disorder does not usually cause a lot of problems in a person’s life style. They can, however, become disruptive and annoying.

A lot of people have the common eye twitch on occasion. It is nothing to worry about. However, if it becomes very repetitive, you may have a transient tic. Treatment for tics depends on how bad you have them. For transient tics, there is no treatment. You just have to learn to deal with them. On the bright side though, they only last for, at most, a year. For chronic cases that could lead to Tourette’s syndrome, doctors often prescribe medication to help settle the tics a little but mainly suggest behavioral therapy to teach patients how to cope with their disorder.

Tortora, Gerald J, Bryan Dickerson. Principles of Anatomy and Physiology. New York: Wiley, 2012. Print.

“Tic Disorders and Twitches.” Brain & Nervous System Health Center. WebMD, 03 Jan. 2012. Web. 02 Apr. 2013. <http://www.webmd.com/brain/tic-disorders-and_twitches?page=2>.

Autobiographical Memory and the Brain

Do you have a highly superior autobiographical memory? Meaning, can you tell your life’s story from childhood to present with effortless ease? Let me give you a quick quiz. Describe your day on March 14, 2002. Unless this day was your birthday or of special significance to you, the likelihood of you succeeding to fulfill my request is rare. However, if you were successful, your brain may be different, not only in your experiences and knowledge but even in functioning and composition.

This unique ability to recall information has been studied by the University of California, Irvine (UCI) Center for Neurobiology of Learning and Memory. A study of eleven people with highly superior autobiographical memory has showed a distinction in nine structures of the brain. More white matter was located between the frontal lobe and the parietal region. Most other differences were in parts of the brain known to have a link to autobiographical memory.  The memories have 99% accuracy beyond around ten years old. Other correlations were found between the study’s subjects. Obsessive-compulsive tendencies, which may or may not be associated with their memory capabilities, were prevalent among the group. Also, a common hobby of the subjects was having incredibly organized collections of a wide range of objects.

Another unusual aspect of these findings is that these people with highly superior autobiographical memory did not have extraordinary memory capabilities in other categories of memory such as mass amounts of facts or intellectual material. This gives a refining to the area of autobiographical memory. The separation of one type of memory from another may lead to a better understanding of the memory processes and how they develop variation from possibly genetics or in linkage and cooperation between brain structures. An exciting alternative explanation is that experiences and training can lead to these changes in the brain.

 

References:

Cleary, Anne, Ph.D.. “People with Extraordinary Autobiographical Memory | Quirks of     Memory.” Psychology Today: Health, Help, Happiness + Find a Therapist. Sussex   Publishers, LLC, 9 Jan. 2013. Web. 19 Apr. 2013.

University of California – Irvine. “Brains are different in people with highly superior autobiographical memory.” ScienceDaily, 30 Jul. 2012. Web. 19 Apr. 2013.

 

 

Toads’ Leaping Legs

Toads are generally known for their warts. However, the toad’s impressive attribute is its strong, powerful leg musculature. While the jumping distance is noteworthy, the landing ability is what is interesting to biologist Emanuel Azizi. The studies he performed involved the toad’s ability to protect its leg muscles by bracing for specific impact intensities.

When jumping, toads’ leg muscles contract. When landing, these muscles stretch. The body comes to a complete stop after moving at a fairly high speed due to the muscles acting as brakes. To disperse the energy and force of impact, the muscles of the legs take the risk of overstretching and possible injuries. A neuromuscular response to shorten the leg muscles that are involved in landing protects the muscles during larger impacts from jumping longer distances. How much the muscles shorten depends on the distance of the jump. The nervous system adapts the motor control patterns with each individual jump.

These findings can be applied to rehabilitation programs in the future. Neuromuscular deficiencies may be better understood by the looking at the strength and precision of the nervous system adaptations in toads. With further study into the sensory information being reported to the nervous system which enables the quick defensive measures to prevent injury, improvements can be made to the way we treat strains and overstretching injuries of muscles in humans.

References:

Nogrady, Bianca. “Toads Tweak Muscle Length to Soften Impact › News in Science (ABC Science).” Toads             Tweak Muscle Length to Soften Impact › News in Science (ABC Science). Australia’s Broadcasting              Company, 19 Dec. 2012. Web. 03 Apr. 2013.

University of California – Irvine. “Leaping toads reveal muscle-protecting mechanism.” ScienceDaily, 19  Dec. 2012. Web. 2 Apr. 2013.

Vitiligo

Arial Donnell

Vitiligo is a skin disease, which causes loss of color and white patches on the skin. The development of vitiligo occurs when the partial or complete loss of melanocytes produce irregular white spots (1). In the United States alone, the disease affects 1 in 200 people, and is much more noticeable among individuals with a darker complexion. As of now, no cure exists for vitiligo, but it is treated and managed by light therapy, creams, tropical medications, and skin transplants (2).

A new study has revealed skin transplant surgery is effective in treating vitiligo. Henry Ford Hospital was the first in America to try the surgery known as, melanocyte-keratinocyte transplant, or MKPT. The surgery places patients under anesthesia while taken skin cells from normally pigmented areas and replacing them to the damaged area of skin (2). Researches tested a group of men and women and checked their progress for up to six months. Drastic changes had taken place in the six-month span. More than half of the affected area was covered with their natural skin color.

The new study will have a great impact on people who are affected by the disease. Although the results did not show that the surgery was a hundred percent in replacing the white patches with ones natural skin tone, I think people who suffer from the disease will be satisfied for the amount that does. To me, this is a big confidence booster and will raise the self-esteem of the patient.

 

 

Tortora, Gerard J., and Bryan Derrickson. Principles of Anatomy and Physiology. Hoboken, NJ: John Wiley & Sons, 2010. Print.

Henry Ford Health System. “Skin transplant offers new hope to vitiligo patients.” ScienceDaily, 10 Mar. 2010. Web. 28 Feb. 2013.