Mononucleosis Vaccination Possibility

The Epstein-Barr Virus causes infectious mononucleosis, also commonly known as “mono”. Mono is a contagious disease that is most often found in children and young adults, and it is common to be spread by intimate oral contact, which gives it its name the “kissing disease”. The B cells are the primary host cells for this virus, which are infected by the multiplication of the EBV in lymphatic tissues that then moves into the blood. The B cells appearance changes to the point that they resemble a monocyte. If one was to look at the infected B cells, they would notice that they have become enlarged and abnormal. The virus increases the white blood cell count by a high percentage of lymphocytes. There are many signs and symptoms, such as fatigue, headache, dizziness, sore throat, enlarged and tender lymph nodes, and fever. No cure has been found to cure mono, but there has been research done on young killer cells that protect against the infectious disease.

            According to an article I read about young killer cells protection against mono, it is common for people to be carriers of the Epstein-Barr Virus. However, some people are not carriers, and the age one becomes infected with this virus can determine one’s illness. For instance, the article mentions that, as an adult, getting infected will more likely cause them to become ill, whereas, a child who is infected is less likely to become ill because of his innate immune system. This is because, according to immunologists from the University of Zurich, young natural killer cells fight off the infectious disease, and children’s innate immune system has an abundance of these young natural killer cells. This means that adolescents and adults who do not have these young natural killer cells are more likely to get infected and become ill. However, this group from the University of Zurich is working on finding a vaccination that could protect people from getting infected by this disease.

If they find a vaccination that keeps more people from getting EBV who can’t fight it off because they don’t have the young natural killer cells, it will reduce healthcare costs and work loss for the one at risk of getting ill. If one gets infected, not only do they have to pay for the care given to them by their doctor or whoever they see, but also they lose time at work. This will cause a problem with them being able to not only pay for personal necessities but also their Healthcare. As a whole society, Healthcare costs increases everybody’s insurance costs, and work loss costs everyone involved in productivity and sick time, whether it is short term disability, long term disability, or elderly care if they do become disabled. Therefore, if a vaccination is found, it can tremendously help with the costs of Healthcare and work loss for individuals or society as a whole.

 

 

Tortora, Gerard J and Derrickson, Bryan. Princciples of Anatomy and Physiology 13th     Edition. John Wiley & Sons, Inc. 2011. 30 Jan. 2014.

University of Zurich. “Young killer cells protect against infectious mononucleosis.”         ScienceDaily. ScienceDaily, 19 December 2013.           <www.sciencedaily.com/releases/2013/12/131219130145.htm>.

Respiratory Syncytial Virus (RSV)

Respiratory Syncytial Virus (RSV)

We have all seen the commercials with the infants that are coughing hysterically due to RSV. But, do we actually even know what RSV is. Newborn babies have immature immune systems which can cause infections of the lungs and breathing passages. RSV is a major cause of respiratory illness in young children. RSV is highly contagious and usually spread through coughing and sneezing. RSV if severe, can lead to bronchiolitis or pneumonia. RSV has estimated to cause over 14,000 deaths yearly in the United States.

Barney Graham and his colleagues at US National Institute of Allergy and Infectious Diseases are researching the early immune system in order to develop effective vaccines for newborns to infants. Graham and colleagues studied the behavior of these lung dendritic cells in newborn mice and compared it with that in older animals. They learned that the younger the child is the more likely the RSV infection will make intense changes. Also dendritic cells from newborns take up, digest, and present parts of an intruding virus to other immune cells, which is different than it is among adults. This is why adults do not usually get RSV.

Preventing and treating RSV, can be fairly easy. Using hand sanitizer before handling a small child can reduce the chance of the child contracting RSV. Parents should allow time for recovery if the child has contacted RSV. Also, give the child plenty of fluids. If the infant is at risk for RSV, they can be given a monthly injection of medication consisting of RSV antibodies during peak RSV season, which is November through April. You should call the doctor if your child has had thick nasal discharge, high fever, worsening cough, signs of dehydration, or trouble breathing.

Heather Mundlin

http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5908a4.htm

http://www.sciencedaily.com/releases/2014/02/140213184812.htm


 

A Link Between Heartburn and Esophageal Cancer: What You Can Do to Reduce Your Risk

Heartburn, also known as acid reflux and gastroesophageal reflux disease (GERD), is a condition that nearly 60 million adults in the United States alone suffer from. It is a very common condition that attacks generally without warning. Some of its varied causes include, but are not limited to: pregnancy, large meals, eating habits, bending forward, peptic ulcers, and many other causes (Lifespan). Drinking and smoking also cause the sphincters of the esophagus to relax and worsen the problem (Tortora). It has been discovered in the past that only a small percentage of those patients who suffer from heartburn will develop Barrett’s esophagus. Barrett’s esophagus is a condition that is caused by the cells of the lower esophagus becoming damaged. These cells are damaged by repeated exposure to gastric juices and stomach acid (Lifespan).

These few percentiles of patients who suffer from heartburn that are later diagnosed with Barrett’s esophagus have now been found to have a higher risk of developing esophageal cancer. Although this is bad news, surprisingly good news has also been found. This link between esophagus cancer and heartburn can be blocked by total suppression of stomach acid, a job that can be done with a proton pump inhibitor, such as omeprazole (Lifespan). Omeprazole’s job in the body is to decrease the amount of acid produced in the stomach, that way less acid travels into the esophagus. Omeprazole is not only used as a daily medication to decrease acid produced, it also promotes healing of the esophageal damage caused by stomach acid (What).

This is good news for people who suffer from heartburn and those who have had a diagnosis of Barrett’s esophagus. These over-the-counter and prescription-given proton pump inhibitors, like omeprazole, could greatly reduce the risk of esophageal cancer. This gives hope to patients who suffer from Barrett’s esophagus, because the proton pump inhibitors could bring healing to the esophagus. This is good news for families everywhere, and a discovery that could lower the risk of esophageal cancer for the patients that are most at risk.

 

Lifespan. “Pathway uncovered linking heartburn, esophageal cancer.” ScienceDaily. ScienceDaily, 7 October 2013. <www.sciencedaily.com/releases/2013/10/131007151833.htm>.

 

Tortora G.J. and B. Derrickson. 2012. Principles of Anatomy and Physiology. 13th ed., John Wiley and Sons

 

“What is omeprazole?.” Drugs.Com. N.p., n.d. Web. 3 Apr. 2014. <http://www.drugs.com/omeprazole.html>.

One Simple Way to Relieve Gastroesophageal Reflux Disease

I’ve always heard of the word “GERD”, but I never knew what it was. GERD is gastroesophageal reflux disease, also known as heart burn. Acid reflux occurs when the stomach contents leak backwards from the stomach into the esophagus. The reason it is called heart burn is because when stomach acid, hydrochloric acid, comes back up, it causes a burning sensation near the heart. Drinking alcohol and smoking increase the problem making the symptoms a lot worse. If you have acid reflux, you should avoid foods that stimulate stomach acid like tomatoes, onions, orange juice, chocolate, coffee, and fatty foods. There are medications you can take that cut down on the severity of the burning sensation. You can take Pepcid or Pepto-Bismol an hour before eating to block the acid coming back up. You are less likely to have severe acid reflux if you eat foods in smaller amounts and if you don’t lie down after eating.  This could also have something to do with cancer of the esophagus (Totora).

Millions of people suffer from acid reflux, especially people over forty years of age. You may notice heartburn, sore throat, chest pains, or coughing; these are all symptoms of GERD. In this study, surgeons use a device to cut down the acid reflux a person has. They take a small, circular beaded ring and apply it directly above the stomach, relaxing the sphincters allowing the food to pass through, but then closing when food it gone. After the procedure, patients can return back to normal eating and daily routines in about a week. With the procedure, it cuts down on medication taken and can be more beneficial than other surgeries. Surgeons only recommend this procedure be done if you have chronic acid reflux.  The LINX device has been approved by FDA and has been tested on over 400 people. Ninety percent of the people who have had this procedure have had the amount of reflux decrease (Science Daily).

I feel that this is a good procedure that could be beneficial to a lot of people, especially with severe heartburn. I chose this topic and article because my mother has really bad acid reflux and the doctors have put her on several medications, like Omeprazole, and none of them help. Seeing all of the positive outcomes of this procedure, I would definitely recommend it. I don’t think people realize that heartburn is a serious matter that needs medical attention. If you go so long without attention, it could lead to way worse.

 

Stony Brook University. “Implantable magnetic ‘bracelet’ brings relief to GERD sufferers.” ScienceDaily. ScienceDaily, 27 February 2014. <www.sciencedaily.com/releases/2014/02/140227163835.htm>.

 

Totora, Gerard J., And Derrickson, Bryan. Principals of Anatomy & Physiology. 13th ed. Hoboken: John Wiley & Sons, Inc., 2014. Print.

Dark Chocolate- Good for the Heart

Have A Piece of Dark Chocolate

            Do you have high blood pressure? Eat a dark chocolate truffle. Cardiovascular disease is the leading cause of death worldwide. One piece of dark chocolate a day can’t keep the doctors away, but it can help prevent you from having a stroke or even a heart attack. Dark chocolate is a great source of antioxidants, which can help strengthen your ability to fight infection and diseases.

We all know atherosclerosis is when arteries become stiff and white blood cells stick to the walls of blood vessels. By adding a piece of dark chocolate everyday it can help restore flexibility to arteries and prevent those white blood cells from sticking to the walls. Dr. Esser and his colleagues at Wageningen University in the Netherlands recently evaluated 44 middle-aged overweight men over two separate 4- week periods that had two ounces of chocolate per day. The study showed that the chocolate consumption increased endothelium-dependent vasodilation.

Dark chocolate has a number of ways it can improve other health problems such as, decreasing your LDL cholesterol, reducing your rick of getting blood clots, increasing blood flow in arteries and the heart. Dark chocolate has even been found to improve mood by boosting the serotonin and endorphins in the brain. Also beware, dark chocolate is high in fat and calories, so be sure to eat right and balance out those extra pieces of dark chocolate. Go ahead and indulge in a sweet sugary goodness, and do not feel guilty because you’re helping your heart out!

Heather Mundlin

http://www.fasebj.org/content/28/3/1464.abstract

http://www.sciencedaily.com/releases/2014/02/140227092149.htm

Meniere’s Disease: The First Step Towards the Right Direction.

Meniere’s disease is a very aggressive disorder that affects our organs of audition (hearing) and equilibrium, the cochlea (contains the organ of corti, and produces nerve impulses from the vibrations of sounds) and vestibule of the inner ear, respectively. Persons suffering from Meniere’s disease will have symptoms such as attacks of dizziness (vertigo), ringing of the ears (tinnitus), and hearing loss. This happens because the amount of fluid, endolymph, in the labyrinth increases which increases pressure on the delicate organs of the inner ear. Meniere’s disease can happen at any age but is most common in older adults between the ages of 40-60 years old. This disease usually only effects one ear and over a period of several years can cause deafness.

There are cochlear implants to replace lost hearing that results from inner ear damage, however, for people who suffer with balance disorders, there has not been any treatments. Christopher Phillips and his colleagues from the University of Washington developed a vestibular prosthesis that will give an electrical stimulation in the semi-circular canals’ fluid of the ear. When this happens the fluid manipulates the brain into thinking the body is swaying or moving in a particular direction. When the brain is tricked it causes a compensatory postural reflex that will stabilize the body posture which helps to restore balance and stop the dizzy feeling.

This discovery is actually pretty cool and cleaver by manipulating the brain. This is clearly a first step into finding a cure or way to help with a balance disorder resulting from an inner ear disease. It will help people who suffer from this disease recover their balance and be able to function in daily life properly. I am sure that the people who suffer from this disease is very thrilled that there may be a stop to their complications.

  1. http://www.sciencedaily.com/releases/2013/06/130613104137.htm
  2. A&P class lecture text

Prevention of Cataracts

            Being able to see is an important thing. However, there are several causes for blindness. One in particular, which I am going to discuss, is a very common one where there is a loss of transparency of the lens called cataract. Cataracts occur when the lens crystalline protein structure changes and your vision becomes blurry because the lens has become less transparent. Several things can cause cataracts like aging, long exposure to ultraviolet light, or even a disease such as diabetes. Yes, there are ways to fix this like replacing the old lens with a new artificial one. However, I looked up ways to prevent cataracts, and I came across an article about statins that prevent cataracts.

            Statins are cholesterol– lowering drugs, usually for fighting heart disease; however, researchers have found they help decrease the risk of cataracts as well.  In this article, Dr. Gabriel Chodick explains that these drugs can help prevent inflammation in the eye and stop the process of oxidation on the ocular nerve celss. Dr. Chodick did a study of 180,000 patients from 1998-2007 to observe the effect statins had on cataracts. His study showed a strong association with a large population. Also, what he found was that the daily intake of statins in men from the age 45-54 decreased their risk of developing cataracts by 38%, and although statins were not as effective in women, they still had an 18% decrease in the risk of developing cataracts. The article also states that 10% of people who are prescribed statins rarely take them; however, the doctor says now they have reason to continue taking this drug. This article has also helped me understand the importance of finding a prevention for cataracts for our society.

            The article also explains that in the U.S., cataracts affect about 60%- of  men and women over the age of 60. The use of statin drugs could help to lower the number of men and women in society who have blindness due to cataracts. Also, blindness doesn’t only affect the person with the loss of sight but also the people close to the person. Preventing blindness is not just helping someone to see, but also it is helping someone keep contact with the environment around them. As well as contact with the environment around them, people who are affected with blindness tend to have a low self-esteem due to the need for help and emptiness because the sight is a major sense to any human. However, the prevention of cataracts by this drug will benefit someone as well. For instance, the person would have an increased ability to work, a decreased disability cost, longer independence for individuals, and prolonged vision. Blindness affects ones everyday life. Therefore, this drug, known as statin, could help individuals with his or her life in general.

 

 

 

 

 

Tel Aviv University. “Common cholesterol drugs, statins, fight cataracts, too.”       ScienceDaily. ScienceDaily, 11 February 2010.

Tortora, Gerard J and Derrickson, Bryan. Princciples of Anatomy and Physiology 13th       Edition. John Wiley & Sons, Inc. 2011. 30 Jan. 2014.

 

Oral Cancer

Oral cancer is a growing disease among people, and it is battled everyday. This disease not only affects your body in many ways, but it can be deadly as well. Oral cancer has the ability to affect the whole inside of the mouth, but it is more dangerous when the cancer affects the tongue. One main concern occurs when the tongue tissues are removed. When the tissues are removed the individual  has less tongue mass, and they are more vulnerable to letting food and liquids into their lungs.  Researches have yet to find a cure but continue to search for what causes the disease, how to prevent it, and how to improve treatments.

Most research that has been done toward oral cancer has focused on the DNA of the cells to see what might be causing the cancer. Research has shown that a mutation in the p53 gene is related to the cause of oral cancer. The p53 gene is linked to controlling the cells from growing to much. When there is a mutation in this gene growth of the cells is not controlled and the cancerous cells can grow rapidly.

Oral cancer affects a great amount of people a year. Studies and research show that about 34,000 people a year are diagnosed with oral cancer. Surgeons at Washington University School of Medicine in St. Louis worked hard In the past years to help those who suffer from oral cancer. The surgeons developed new and improved ways of reconstructing the tongue after the cancerous areas were removed. This new development has helped patients feel more normal by helping them with their speech as well as their swallowing ability.

Citations
http://www.cancer.org/cancer/oralcavityandoropharyngealcancer/detailedguide/oral-cavity-and-oropharyngeal-cancer-new-research

http://oralcancerguide.org/?p=262

http://www.siteman.wustl.edu/ContentPage.aspx?id=561#sthash.8h6ZjieX.dpuf

Sickle Cell Disease: The Sickle Shape Illuminated

                Sickle cell disease is a disorder that affects a person’s red blood cells (erythrocytes). Sickle cell is a red blood cell that does not have the appearance of a normal, healthy red blood cell. Abnormal hemoglobin molecules (the molecules inside of erythrocytes that carry oxygen) of people who suffer from sickle cell disease cause the characteristic crescent moon shape seen in their erythrocytes. The abnormal shape of sickle cells tends to form blockages in the blood vessels, which in turn halts oxygen from traveling to the affected tissues. Also, the abnormal hemoglobin forms fibers causing stiffness, which makes them stick together and does not allow for the normal, free mobility that normal red blood cells have.

                Dr. Frank Ferrone, from Drexel University in Philadelphia, and Dr. Yihua Wang, from the Mayo Clinic in Rochester, along with many other researchers came up with an extraordinary discovery on sickle cells and why they stick together in sickle cell disease. The researchers experimented with different techniques involving light scattering, and they found that light rays are drastically affected by the arrangement of the hemoglobin fibers that form in sickled red blood cells. They found that areas of the hemoglobin molecules that should repel each other instead stick together resulting in the abnormal shape. The light patterns are reflecting on how the fibers are arranged and what causes sickle cell disease. Their discovery on how they can use light to determine how the fibers were arranged made it possible to compare and contrast sickle cells vs. normal red blood cells. 

This research has brought insight into the formation of the fibers in the sickle cells and it can further research on how to correct the abnormal fibers. What the researchers have discovered can lead to future cures using drugs that can possibly alter and change what is the source of the issue involving the fibers. The experiment gives insight to the researchers because they were able to study the structures of sickle cells based on how the light refracted. They were also able to determine how the abnormal shape leads to the abnormal formation of the fibers in these sickle cells. It is incredible how they were able to use light as a source to determine the difference in the structure of hemoglobin fibers in sickle cells in comparison to the fibers in normal, healthy hemoglobin. This research can greatly impact those that suffer from sickle cell disease by possibly finding a cure, and also giving answers to questions that have been wondered about.

http://www.sciencedaily.com/releases/2013/11/131105121413.htm

http://edugen.wileyplus.com/edugen/student/mainfr.uni

“Contact Lens Capable of Correcting Hyperopia Without Surgery”

One vision problem that people suffer from is hyperopia, in which a person can see things at a distance clearly but not when the objects are up close. The correction of eyesight is done by orthokeratology or ortho-K; which is the reshaping of the cornea. The technique is done with the use of rigid gas-permeable contact lenses over night that will reshape the cornea. The contact lens can also help correct myopia and stigmatism.

In the research Jaume Paume used ten test subjects all suffering from vision problems. With the use of the patient in the trial Jaume Paune developed a lens that was worn at nighttime that corrected the patients with hyperopia. The lens actively applies pressure on the outside of the cornea; which works by reshaping the cornea. Unfortunately the effect is only temporary. The lens must be worn every night to reshape the cornea. The correction to the cornea however will not have lasting affects. The treatment shows promise as an ongoing therapy and an alternative to corrective laser surgery.

The research that Mr. Paune discovered is amazing. It offers patients suffering from vision problems another alternative option then having surgery. The risk with the contact lens is less risky then the patients who undergo surgery. With using the contact lens there is no recovery period or missed work. The lens however is not very cost effective especially since they must be worn every night and replaced from time to time. Personally I feel that this lens still gives patients more options other then surgery.

Kethanne K. Colich

Tortora, Gerard J and Derrickson, Bryan. Principles of Anatomy & Physiology. 13th. 2011.Print.
http://www.sciencedaily.com/releases/2010/04/100420161224.htm