Stem Cell Research finds ways to improve Type 1 Diabetes cures.

Type 1 Diabetes (T1D) is a disorder involving insulin need because the beta cells of the pancreas have been destoyed by the immune system.  The pancreatic beta cells are needed for production of insulin.  The insulin in turn reduces the blood glucose level, keping the body in homeostasis.  Currently the treatment of most T1D is with periodic insulin injections.

Research has been on-going with possible stem cell treatment of the pancreas, renewing beta cell production for insulin.  New studies have found treatment with a new drug called Ig-GAD2 and stem cells can not only lead to  production of new beta cells, it repairs the blood vessels that support beta cell growth and insulin distribution.  Thus beta cell survival is greater and insulin production is renewed.  Research of cures for other autoimmune disorders may apply these findings as well.

As many people are affected by T1D and the need for insulin is a demand, new hope arises for a cure to such a chronic illness.  The possibilities of reversing a genetic illness is a glimmer of psychological and financial hope.  To find a way to reverse this illness is a way to give so many people a new way of life.  No more shots, daily finger-sticks, and timely planning of meals and snacks around the demand of glucose need.

1.)  Tortora, Derrickson.  Principles of Anatomy & Physiology, 13th ed.  New Jersey,     2012.

2.)  University of Missouri School of Medicine (2013, May 29).  Adult stem cells could hold key to cure type 1 diabetes. ScienceDaily.  Retrieved June 16, 2013, from http://www.sciencedaily.com/releases

Adult Brain development

The brain can still develop even after adolescense. Adults need to enhance thier plasticity. Plasicity is when you are able to adapt to new experiences. Being able to adapt to a new and different environment is a social and survival skills that everyone has to have. Being a adult means that life is constantly changing, you have to adapt to having children being married and new jobs. New findings on the adult brain establish two principles. First, the adult brain continues to grow and develop throughout our entire life. Second, brain development in adulthood is shaped mostly by outside stimuli. This new thinking means that we can do healthy “workouts” for our brains, as well as our bodies!

There are games like soduko and lumosity for example. Having new expereincese is the best thing you can do for your brain. Everytime you learn something new your brain creates new pathways. The brain and body are connected and exercise is good for the both of them. The brain increases new cell growth and mental abilities  20-30% from the stimulation of exercise. Our brains can not function properly without sleep. We all need 8 hours of sleep a night so that our brains will function properly. A diet of fruits and vegetable along with plent of water will benefit the brain and body and help everyone function better.

 

Sources: J. Tortora, Gerald, and Bryan Derrickson. Principles of Anatomy and Physiology. 13th ed. John Wiley & Sons, Inc. Hoboken NJ, USA  2012.

“The Adult Brain.” Brain Institute Oregan Health and Science University OHSU is an equal opportunity affirmative action institution 2001-2013.

Twith or Tic???

Twitch or Tic???

Have you ever been sitting in class and all of a sudden your eye lid starts twitching? Well guess what? You could have a tic! Our book gives the example of our eyelids twitching as a tic! The definition is “a spasmodic twitching made involuntarily by muscles that are ordinarily under voluntary control”. So really, every time your eyelid twitches, it’s a tic. Don’t worry though, this does not mean you actually have tics. Tics are just a form of twitches.

WebMD.com tells us that most of the time twitches and tics are harmless, but on some occasions it may be a disorder. Tic disorders have repetitive and numerous twitches. They can actually be suppressed, but it can cause major discomfort to the person. It is not really known as to what causes tics, but lack of sleep and stress seem to play a role. Twitches, on the other hand, are what most people experience. These only happen on occasions and are completely involuntary. Extreme cases of eye twitches are called Blepharospasms, which can resemble an eye blinking tic. However, as stated earlier, the tic is controllable while the twitch is not. A twitch or a tic disorder does not usually cause a lot of problems in a person’s life style. They can, however, become disruptive and annoying.

A lot of people have the common eye twitch on occasion. It is nothing to worry about. However, if it becomes very repetitive, you may have a transient tic. Treatment for tics depends on how bad you have them. For transient tics, there is no treatment. You just have to learn to deal with them. On the bright side though, they only last for, at most, a year. For chronic cases that could lead to Tourette’s syndrome, doctors often prescribe medication to help settle the tics a little but mainly suggest behavioral therapy to teach patients how to cope with their disorder.

Tortora, Gerald J, Bryan Dickerson. Principles of Anatomy and Physiology. New York: Wiley, 2012. Print.

“Tic Disorders and Twitches.” Brain & Nervous System Health Center. WebMD, 03 Jan. 2012. Web. 02 Apr. 2013. <http://www.webmd.com/brain/tic-disorders-and_twitches?page=2>.

Autobiographical Memory and the Brain

Do you have a highly superior autobiographical memory? Meaning, can you tell your life’s story from childhood to present with effortless ease? Let me give you a quick quiz. Describe your day on March 14, 2002. Unless this day was your birthday or of special significance to you, the likelihood of you succeeding to fulfill my request is rare. However, if you were successful, your brain may be different, not only in your experiences and knowledge but even in functioning and composition.

This unique ability to recall information has been studied by the University of California, Irvine (UCI) Center for Neurobiology of Learning and Memory. A study of eleven people with highly superior autobiographical memory has showed a distinction in nine structures of the brain. More white matter was located between the frontal lobe and the parietal region. Most other differences were in parts of the brain known to have a link to autobiographical memory.  The memories have 99% accuracy beyond around ten years old. Other correlations were found between the study’s subjects. Obsessive-compulsive tendencies, which may or may not be associated with their memory capabilities, were prevalent among the group. Also, a common hobby of the subjects was having incredibly organized collections of a wide range of objects.

Another unusual aspect of these findings is that these people with highly superior autobiographical memory did not have extraordinary memory capabilities in other categories of memory such as mass amounts of facts or intellectual material. This gives a refining to the area of autobiographical memory. The separation of one type of memory from another may lead to a better understanding of the memory processes and how they develop variation from possibly genetics or in linkage and cooperation between brain structures. An exciting alternative explanation is that experiences and training can lead to these changes in the brain.

 

References:

Cleary, Anne, Ph.D.. “People with Extraordinary Autobiographical Memory | Quirks of     Memory.” Psychology Today: Health, Help, Happiness + Find a Therapist. Sussex   Publishers, LLC, 9 Jan. 2013. Web. 19 Apr. 2013.

University of California – Irvine. “Brains are different in people with highly superior autobiographical memory.” ScienceDaily, 30 Jul. 2012. Web. 19 Apr. 2013.

 

 

Toads’ Leaping Legs

Toads are generally known for their warts. However, the toad’s impressive attribute is its strong, powerful leg musculature. While the jumping distance is noteworthy, the landing ability is what is interesting to biologist Emanuel Azizi. The studies he performed involved the toad’s ability to protect its leg muscles by bracing for specific impact intensities.

When jumping, toads’ leg muscles contract. When landing, these muscles stretch. The body comes to a complete stop after moving at a fairly high speed due to the muscles acting as brakes. To disperse the energy and force of impact, the muscles of the legs take the risk of overstretching and possible injuries. A neuromuscular response to shorten the leg muscles that are involved in landing protects the muscles during larger impacts from jumping longer distances. How much the muscles shorten depends on the distance of the jump. The nervous system adapts the motor control patterns with each individual jump.

These findings can be applied to rehabilitation programs in the future. Neuromuscular deficiencies may be better understood by the looking at the strength and precision of the nervous system adaptations in toads. With further study into the sensory information being reported to the nervous system which enables the quick defensive measures to prevent injury, improvements can be made to the way we treat strains and overstretching injuries of muscles in humans.

References:

Nogrady, Bianca. “Toads Tweak Muscle Length to Soften Impact › News in Science (ABC Science).” Toads             Tweak Muscle Length to Soften Impact › News in Science (ABC Science). Australia’s Broadcasting              Company, 19 Dec. 2012. Web. 03 Apr. 2013.

University of California – Irvine. “Leaping toads reveal muscle-protecting mechanism.” ScienceDaily, 19  Dec. 2012. Web. 2 Apr. 2013.

Vitiligo

Arial Donnell

Vitiligo is a skin disease, which causes loss of color and white patches on the skin. The development of vitiligo occurs when the partial or complete loss of melanocytes produce irregular white spots (1). In the United States alone, the disease affects 1 in 200 people, and is much more noticeable among individuals with a darker complexion. As of now, no cure exists for vitiligo, but it is treated and managed by light therapy, creams, tropical medications, and skin transplants (2).

A new study has revealed skin transplant surgery is effective in treating vitiligo. Henry Ford Hospital was the first in America to try the surgery known as, melanocyte-keratinocyte transplant, or MKPT. The surgery places patients under anesthesia while taken skin cells from normally pigmented areas and replacing them to the damaged area of skin (2). Researches tested a group of men and women and checked their progress for up to six months. Drastic changes had taken place in the six-month span. More than half of the affected area was covered with their natural skin color.

The new study will have a great impact on people who are affected by the disease. Although the results did not show that the surgery was a hundred percent in replacing the white patches with ones natural skin tone, I think people who suffer from the disease will be satisfied for the amount that does. To me, this is a big confidence booster and will raise the self-esteem of the patient.

 

 

Tortora, Gerard J., and Bryan Derrickson. Principles of Anatomy and Physiology. Hoboken, NJ: John Wiley & Sons, 2010. Print.

Henry Ford Health System. “Skin transplant offers new hope to vitiligo patients.” ScienceDaily, 10 Mar. 2010. Web. 28 Feb. 2013.

 

 

stem cell treatment for stoke

Strokes are cerebrovascular accidents (cva) and are caused by lack of blood flow or blockage to the brain. People at risk of a stroke suffer from high cholesterol, high blood pressure and diabetes. Recent research has shown that stem cells can be used as cellular building blocks and can be administered to stoke patients and result in better recovery of brain function.

Stem cells are undifferentiated cells that divide through mitosis and can regenerate itself to make new cells. Stem cells are being used to cure diseases everyday. Patients receive stem cells intravenously or subcutaneously. The procedure seems to be very safe and promising, it only takes an hour, and has no known negative side effects. For safety precautions, the stem cells that are used go through extensive screening to check for imperfections. Fetal stem cells are used because the body does not reject them because they do not have a cellular fingerprint.

This unique treatment means that patients will not need more medications for their immune system. That helps their bodies be on less medication and save more money. There have been over 2000 men and women treated with these stem cells and the results of their treatments have been promising. There has been substantial improvements in all the patients. It takes patients 3 to 6 months to see any changes and improvements in their treatments.

 

Sources: J. Tortora, Gerald, and Bryan Derrickson. Principles of Anatomy and Physiology. 13th ed. John Wiley & Sons, Inc. Hoboken NJ, USA  2012.

“Breakthrough Stroke Treatment”. www.stemcellofamerica.© 2011 Stem Cell Of America

The Star-nosed Mole and Sensory Receptors

The most sensitive area to touch in a human is located at the fingertips. Touch receptors are densely packed with about one hundred per square centimeter. Pain receptors (nocireceptors) occur at lower ratio. The neurons can respond to these two possible stimuli at the same time. What keeps these signals from mixing?

A look at the star-nosed mole (which is not only the fastest eating mammal, but also the animal with the most touch and pain sensitive organ of any mammal) may help. The most sensitive area is not in its fingers (because it has claws) but on its nose. The star shaped portion of its nose has the highest density of nerve endings with over one hundred thousand fibers per square centimeter of skin. Neurons are packed into these nerve endings. More of these neurons respond to touch rather than pain. This translates into several other mammals as well.

This news is important new research because these same types of receptors have been found in the sensory receptors of humans and mice. The sense of touch and pain are closely related, but knowing how these are sensed simultaneously and differentiated in the cells is still being researched. The goal of these studies is to pinpoint certain genes that distinguish which sensation should reported, touch or pain. Further findings in this field may lead to treatments of chronic pain through new medications or types of therapy.

 

References:

Kimball, John W. “Mechanoreceptors.” Mechanoreceptors. Kimball’s Biology Pages, 19 Feb. 2011. Web. 28 Feb. 2013.     http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/M/Mechanoreceptors.html

Public Library of Science. “Leading by the nose: Star-nosed mole reveals how mammals perceive touch, pain.” ScienceDaily, 30 Jan. 2013. Web. 28 Feb. 2013.             http://www.sciencedaily.com/releases/2013/01/130130184156.htm

 

Osteoporosis

Osteoporosis affects many elderly women every year. Women over 65, postmenopausal and menopausal are at the highest risk and is the age group that is effected by it. Osteoperosis is a condition that effects the bone density. Dense bones can be porus and spongelike which results  in many fractures. Normal bones which are harder to break and aren’t compresssible are made up of proteins, collagen and  calcium. The spine, hips, ribs and wrist are normal areas to get fractured when osteoporosis has effected the bones.

 

Osteoporosis can be treated the best by early detection. Treatment is the preventment of loss of density. There is no complete cure for osteporosis but building bone strength is a good treatment. Lifestyle changes like quitting smoking, exercising reguarly and eating a balanced diet are treatments that have showed improvement in women with osteoporosis. Medications like  alendronate (Fosamax), risedronate (Actonel), raloxifene (Evista), help build bone and prevent further damage.

 

All in all osteoporosis is a condition that makes elderly womens bones dense. It does not mean the end of thier lives but it does mean that they have to change thier lives for the better. And eat right, exercise and stop bad habits like smoking and drinking. Osteoporosis does not have a cure but there are many medicines and methods to treat it that helps rebuild bone density. Once a bone has been fractured no matter if it has osteoporosis or was normal it will never be exactly the same.

 

Sources: J. Tortora, Gerald, and Bryan Derrickson. Principles of Anatomy and Physiology. 13th ed. John Wiley & Sons, Inc. Hoboken NJ, USA  2012.

“Osteoporosis”. www.medicinenet.com. Catherine Burt Driver, MD on 6/6/2012

Stress Can Shrink the Brain

In light of upcoming exams, stress may be on the rise among students. However, students should take extra precautions against falling prey to stress. The physical tolls that stress takes on the body affects homeostasis in the brain and can actually cause the prefrontal cortex to shrink. This portion of the brain controls metabolism, emotions, self control, and the ability to adapt.

Studies have pinpointed which types of stress affect which part of the brain. Stress from a life trauma (more of a prolonged circumstance) can shrink the mood centers of the brain and cause depression and anxiety disorders. Stress from single life events affect emotions and can cause inappropriate emotions or a lack of emotions. Chronic stress from day to day activities does not pose an immediate threat to the size of the brain, but may gradually shrink the prefrontal cortex. This could lead to a person having an unusually difficult time when faced with adversity or life trauma because his or her brain has already eroded from former stressors.

While these are alarming studies in adults, the results are even more of concern for children. Stress and traumas experienced by children can shrink their brains in the area associated with fear and threat. Because the brain is still forming at this time, the damage may be more definitive. Social, emotional, cognitive, and behavioral aspects of children can be affected. If already affected by stressors in life, maintaining current brain health and even reversing some of the effects of stress may be possible through exercise, meditation, and positive social relationships.

 

Park, Alice. “Study: Stress Shrinks the Brain and Lowers Our Ability to Cope with Adversity | TIME.com.” Time. Time, 09 Jan. 2012. Web. 31 Jan. 2013.

Perry, Bruce D. and Pollard, Ronnie. “Homeostasis, stress, trauma, and adaptation: A neurodevelopmental view of childhood trauma.” Database: PsychINFO. Child and Adolescent Psychiatric Clinics of North America,  Vol 7(1), Jan   1998, 33-51.