Heart Condition: Arrhythmia Culprit Caught in Action

For the heart to contract several steps have to occur, but one main component used to make the heart contract is calcium. Calcium binding allows for actin and myosin to develop tension which influences the strength of the heart contraction (Tortorra and Derrickson). However, substances can alter a change of calcium flowing through the calcium channels leading the heart to beat too fast or too slow in a condition called arrhythmia (Tortorra and Derrickson). Many diseases and conditions are associated with arrhythmia, such as sudden heart attacks in healthy people, which has researchers wondering what causes this.

With the utilization of powerful X-rays, University of British Columbia researches have managed to create an animated model that shows how gene mutations can affect the beating of the heart (ScienceDaily).  After calcium enters the muscle cells of the heart a special protein is in charge of opening the calcium channels that allow for calcium to be released and consequently make the heart contract (ScienceDaily). A gene mutation in the special protein controlling calcium release has been linked to arrhythmia, and other cardiac problems (ScienceDaily). With the construction of a 3D animated model of how the gene mutation of the special protein affects heart contraction, researchers can now better understand how this mutation can be corrected, and therefore possibly save lives (ScienceDaily).

Our hearts beat to the sound of calcium, but gene mutations such as the one that affects the special protein of the calcium channels can lead to serious health risks, and that is why the creation of a 3D model is so important. With a 3D model of the gene mutation researchers are allowed to visibly see such a mutation and watch it in action as it would occur in real life. Therefore, from this model, possible treatments can be made that would prevent or diminish heart related conditions caused by the gene mutation in the special protein. Arrhythmia, at its worst, can cause death, but further research and the utilization of this 3D model can help lower arrhythmia related conditions of the heart (ScienceDaily).

Tortora G.J. and B. Derrickson. 2012. Principles of Anatomy and Physiology. 13th ed., John Wiley and Sons

University of British Columbia (2013, February 17). Heart condition: Arrhythmia culprit caught   in action. ScienceDaily. Retrieved February 25, 2013, from http://www.sciencedaily.com/releases/2013/02/130217134214.htm

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